Translational suppression of calpain blocks long-term potentiation.
نویسندگان
چکیده
منابع مشابه
Translational suppression of calpain blocks long-term potentiation.
Transfection with antisense oligonucleotides was used to reduce calpain 1 activity to approximately 50% of normal values in cultured hippocampal slices. This had no detectable effects on baseline synaptic responses but greatly reduced the incidence and magnitude of long-term potentiation induced with a theta-burst stimulation paradigm. These results suggest that activation of calpain by repetit...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 1996
ISSN: 1072-0502
DOI: 10.1101/lm.3.2-3.209